Dr. Matthew Saderholm
Dean of Faculty; Professor of Chemistry|Chemistry
Office Location
Lincoln Hall, 320
Office Hours
  • If you must make an appointment with Matt, please call 859-985-3487.
  • Allied Health Chemistry
  • Foundations in Chemistry
  • Accelerated General Chemistry
  • Organic Chemistry I
  • Organic Chemistry II
  • Foundations in Biochemistry
  • Biochemistry I
  • Biochemistry II
  • Advanced Lab I
  • Advanced Lab II
  • Research Methods in Peptide Synthesis
  • Chemical Magic
  • Scientific Knowledge and Inquiry
  • Global Issues since 1945
  • Seminar in Contemporary Global Issues
  • The Science of Fermentation

Dr. Saderholm was appointed Dean of the Faculty on July 1, 2019. In this role, he serves as the chief administrator of the teaching faculty. In association with the Provost, he is responsible for the efficacy of the departments of instruction; instruction of the student body; the recruitment, hiring, workload, and performance review of the faculty; maintaining the effectiveness and well-being of the faculty; and maintenance and review of the curriculum.

Dr. Saderholm graduated from Berea College with a B.A. in Chemistry in 1992, after which he spent a year at the Swiss Federal Institute of Technology in Zürich, Switzerland (ETHZ) on a Fulbright Fellowship studying physical and biochemistry. He received his Ph.D. in Biological Chemistry from the University of North Carolina in Chapel Hill in 1998 where he studied de novo protein engineering in the lab of Bruce Erickson. Before joining the Berea College Chemistry faculty, Dr. Saderholm completed a post-doctoral fellowship in enzymology in the laboratory of Carol Fierke at Duke University, studying the enzyme protein farnesyltransferase. Since joining Berea College he has taught across the Chemistry and General Education curriculum and served in many administrative leadership positions, including Department Chair, Division Chair, and Faculty Project Shepherd for the Margaret A. Cargill Natural Sciences and Health Building. He has also traveled abroad repeatedly, visiting the Galapagos Islands on a faculty development trip and teaching an international class on the Science of Fermentation in Germany and France.

Dr. Saderholm’s research interests focus on two main themes: 1) experimental biochemistry experiments that use peptides to probe protein structure and function and 2) increasing the effectiveness of STEM teaching methods through peer-reviewed and data-driven changes in pedagogy.


Dean of the Faculty 2019-present; Natural Sciences, Mathematics, and Nursing Division Chair 2015-2019; Professor of Biochemistry; Department Chairperson 2011-2015; MAC Building Shepherd 2014-2019, started at Berea College in Fall 1998.

  • Ph.D., University of North Carolina at Chapel Hill, 1998
  • B.A., Berea College, 1992
Publications & Works
  • Special Interests

    • Solid-Phase Peptide Synthesis
    • Enzymology
    • Protein Structure
    • Mass Spectrometry
    • Active Learning in STEM Classes
    • Using Chemistry Demonstrations in Service Learning and Outreach Activities
    • How the Design of Learning Spaces Impacts Learning
  • Papers and Publications

    • Kroll, M., Yan, Y., Lim, A., Kearney, J., Dukes, K., Saderholm, M., and Erickson, B., Engineering of Betabellins 15D and 12/15: Two Beta Proteins that Bind Divalent Metal Ions. Peptides: Chemistry, Structure and Biology (Proceedings of the14th American Peptide Symposium), 1995, 563-564.
    • McCafferty, D., Friesen, D., Danielson, E., Wall, C., Saderholm, M., Erickson, B., and Meyer, T., Photochemical Energy Conversion in a Helical Oligoproline Assembly. Proc. Natl. Acad. Sci. USA. 1996 92 (16), 8200-8204.
    • Lim, A., Saderholm, M., Kroll, M., Yan, Y., Makhov, A., Griffith, J., and Erickson, B., Engineering of Betabellin 15D: a 64-Residue Beta-sheet Protein that Forms Long Narrow Multimeric Fibrils. Protein Sci. 1998 7 (7), 1545-1554.
    • Lim, A., Guy, P., Makhov, A., Saderholm, M., Kroll, M., Yan, Y., Anderegg, R., and Erickson, B., Engineering of Betabellin 15D: Copper(II)-induced Folding of a Fibrillar Beta-sandwich Protein. Lett. Pep. Sci., 1999. 6 (1), 3-14.
    • Nakhle, B., Vestal, T., Saderholm, M., and Erickson, B., Synthesis of an Iron(II)-braced Proline-II Tripod Protein. Lett. Pep. Sci., 1999. 6 (1), 31-43.
    • Saderholm, M. and Erickson, B., Engineering of Deltoid and Reduced Deltoid: Two Chimeric Proteins Containing the Oligomerization Site of the Hepatitis Delta Antigen. Lett. Pep. Sci., 1999. 6 (1) 23-30.
    • Lim, A., Makhov, A., Saderholm, M., Griffith, J., and Erickson, B., Engineering of Betabellin 16D: A Beta-sandwich Protein that Forms Narrow Fibrils that Associate into Broad Ribbons. Biochem. Biophys. Res. Comm., 1999. 264, 498-504.
    • Guy, P., Lim, A., Saderholm, M., Yan, Y., Erickson, B., and Anderegg, R.J., Metal-Ion Binding and Limited Proteolysis of Betabellin 15D, a Designed Beta-sandwich Protein. J. Am. Soc. Mass Spec., 1999. 10 (10), 969-974.
    • Saderholm, M., Saconn, P., Shah, N., and Erickson, B. Engineering of Cysteine-containing Variants of Quadrin and Deltoid, Two Proteins Containing the Oligomerization Site of the Hepatitis Delta Antigen. Peptides for the New Millennium (Proceedings of the 16th American Peptide Symposium), 2000. 463-464.
    • Saderholm, M., Hightower, K., and Fierke, C., Protein Farnesyltransferase Exhibits pH-dependent Activity Towards H-Ras Peptide Substrates. Biochemistry, 2000. 39(40), 12398-12405.
    • Roecker, L., Baltisberger, J., Saderholm, M., Smithson, P., and Blair, L., A Science Portfolio, Journal of College Science Teaching, 2007. January, 36-44.
    • Saderholm, M., Lemon, S., and Erickson, B., Characterization of Deltoid and Reduced Deltoid: Two Chimeric Proteins Containing the Oligomerization Site of Hepatitis Delta Antigen. Biopolymers. 2007. 88(5), 764-73.
    • Saderholm, M., and Reynolds, A., Jmol-Enhanced Biochemistry Research Projects. Journal of Chemical Education, 2011. 88(8), 1074-1078.