Chemistry Program

Dr. Matthew Saderholm

Chair of Academic Division 1 (Biology, Chemistry, Physics, Mathematics, and Nursing)

Associate Professor of Chemistry

At Berea College since 1999

Contact Information:

303 Hall Science Building
CPO 2191
Berea, KY 40404

saderholmm@berea.edu
859.985.3322

Fall 2014 Office Hours:

MWF 1-2 pm
TR 9-11 am

Class Schedule:

CHM 345  (Mon/Wed/Fri: 9:20 am – 10:30 am)

Degrees

  • B.A. , Berea College, 1992
  • Ph.D., University of North Carolina, Chapel Hill, 1998

Honors and Awards

  • College Honors Scholarship, University of Alabama in Huntsville.
  • Undergraduate Research Fellowship, University of Alabama in Huntsville.
  • Phi Kappa Phi National Honor Society, Berea College.
  • Fulbright Fellowship, ETH, Zürich, Switzerland.
  • Thomas J. Watson Fellowship, (Accepted Fulbright Fellowship instead).
  • Charles N. Reilley Fellowship, University of North Carolina at Chapel Hill.
  • American Peptide Symposium Young Investigator’s Minisymposium Speaker.
  • Fifteenth American Peptide Symposium Poster Competition, third place.
  • American Peptide Symposium Young Investigator’s Minisymposium Speaker.
  • NIH Postdoctoral Fellowship (Accepted Berea College professorship instead).
  • Kentucky Academy of Science Undergraduate Research Competition, second place in physical sciences poster presentation (won by my student, Fred Boggs)

Affiliations

  • Member, American Peptide Society
  • Member, American Chemical Society
  • Member, Kentucky Academy of Science

Papers and Publications

  • Kroll, M., Yan, Y., Lim, A., Kearney, J., Dukes, K., Saderholm, M., and Erickson, B., Engineering of Betabellins 15D and 12/15: Two Beta Proteins that Bind Divalent Metal Ions. Peptides: Chemistry, Structure and Biology (Proceedings of the14th American Peptide Symposium), 1995, 563-564.
  • McCafferty, D., Friesen, D., Danielson, E., Wall, C., Saderholm, M., Erickson, B., and Meyer, T., Photochemical Energy Conversion in a Helical Oligoproline Assembly. Proc. Natl. Acad. Sci. USA. 1996 92 (16), 8200-8204.
  • Lim, A., Saderholm, M., Kroll, M., Yan, Y., Makhov, A., Griffith, J., and Erickson, B., Engineering of Betabellin 15D: a 64-Residue Beta-sheet Protein that Forms Long Narrow Multimeric Fibrils. Protein Sci. 1998 7 (7), 1545-1554.
  • Lim, A., Guy, P., Makhov, A., Saderholm, M., Kroll, M., Yan, Y., Anderegg, R., and Erickson, B., Engineering of Betabellin 15D: Copper(II)-induced Folding of a Fibraller Beta-sandwich Protein. Lett. Pep. Sci., 1999. 6 (1), 3-14.
  • Nakhle, B., Vestal, T., Saderholm, M., and Erickson, B., Synthesis of an Iron(II)-braced Proline-II Tripod Protein. Lett. Pep. Sci., 1999. 6 (1), 31-43.
  • Saderholm, M. and Erickson, B., Engineering of Deltoid and Reduced Deltoid: Two Chimeric Proteins Containing the Oligomerization Site of the Hepatitis Delta Antigen. Lett. Pep. Sci., 1999. 6 (1) 23-30.
  • Lim, A., Makhov, A., Saderholm, M., Griffith, J., and Erickson, B., Engineering of Betabellin 16D: A Betasandwich Protein that Forms Narrow Fibrils that Associate into Broad Ribbons. Biochem. Biophys. Res. Comm., 1999. 264, 498-504.
  • Guy, P., Lim, A., Saderholm, M., Yan, Y., Erickson, B., and Anderegg, R.J., Metal-Ion Binding and Limited Proteolysis of Betabellin 15D, a Designed Beta-sandwich Protein. J. Am. Soc. Mass Spec., 1999. 10 (10), 969-974.
  • Saderholm, M., Saconn, P., Shah, N., and Erickson, B. Engineering of Cysteine-containing Variants of Quadrin and Deltoid, Two Proteins Containing the Oligomerization Site of the Hepatitis Delta Antigen. Peptides for the New Millennium (Proceedings of the 16th American Peptide Symposium), 2000. 463-464.
  • Saderholm, M., Hightower, K., and Fierke, C., Protein Farnesyltransferase Exhibits pH-dependent Activity Towards H-Ras Peptide Substrates. Biochemistry, 2000. 39(40), 12398-12405.
  • Roecker, L., Baltisberger, J., Saderholm, M., Smithson, P., and Blair, L., A Science Portfolio, Journal of College Science Teaching, 2007. January, 36-44.
  • Saderholm, M., Lemon, S., and Erickson, B., Characterization of Deltoid and Reduced Deltoid: Two Chimeric Proteins Containing the Oligomerization Site of Hepatitis Delta Antigen. Biopolymers. 2007. 88(5), 764-73.
  • Saderholm, M., and Reynolds, A., Jmol-Enhanced Biochemistry Research Projects. Journal of Chemical Education, 2011. 88(8), 1074-1078.

Research Programs

  • Implementing active-learning pedagogies for undergraduate chemistry classes
  • Molecular modeling of peptides and proteins
  • Investigation of the mechanism of the neuropeptidase neurolysin using solid-phase peptide synthesis & enzyme kinetics methodologies
  • Increasing the use of mass spectrometry in undergraduate chemistry labs
  • Characterization of the active compounds in regional ginseng samples

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