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Dr. Matthew Saderholm
Assistant Professor of Chemistry
Science,
Room 303
CPO 1996
Phone: 859-985-3322
Fax: 859-985-3303
E-Mail:
At Berea College since 1999
| Degrees |
- B.A. , Berea
College, 1992
- Ph.D., University
of North Carolina, Chapel Hill, 1998
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| Honors and Awards |
- College
Honors Scholarship, University of Alabama in Huntsville.
- Undergraduate
Research Fellowship, University of Alabama in Huntsville.
- Phi Kappa
Phi National Honor Society, Berea College.
- Fulbright
Fellowship, ETH, Zürich, Switzerland.
- Thomas J.
Watson Fellowship, (Accepted Fulbright Fellowship instead).
- Charles
N. Reilley Fellowship, University of North Carolina
at Chapel Hill.
- American
Peptide Symposium Young Investigator’s Minisymposium
Speaker.
- Fifteenth
American Peptide Symposium Poster Competition, third
place.
- American
Peptide Symposium Young Investigator’s Minisymposium
Speaker.
- NIH Postdoctoral
Fellowship (Accepted Berea College professorship instead).
- Kentucky
Academy of Science Undergraduate Research Competition,
second place in
physical sciences poster presentation (won by my student,
Fred Boggs)
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| Affiliations |
- Member,
American Peptide Society
- Member,
American Chemical Society
- Member,
Kentucky Academy of Science
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| Papers and Publications |
- Kroll, M., Yan, Y.,
Lim, A., Kearney, J., Dukes, K., Saderholm, M., and
Erickson, B., Engineering of
Betabellins 15D and 12/15: Two Beta Proteins that Bind
Divalent Metal Ions. Peptides: Chemistry,
Structure and Biology (Proceedings of the14th American
Peptide Symposium), 1995, 563-564.
- McCafferty, D., Friesen,
D., Danielson, E., Wall, C., Saderholm, M., Erickson,
B., and Meyer, T.,
Photochemical Energy Conversion in a Helical Oligoproline
Assembly. Proc. Natl. Acad. Sci. USA. 1996
92 (16), 8200-8204.
- Lim, A., Saderholm,
M., Kroll, M., Yan, Y., Makhov, A., Griffith, J.,
and Erickson, B., Engineering of
Betabellin 15D: a 64-Residue Beta-sheet Protein that
Forms Long Narrow Multimeric Fibrils. Protein Sci.
1998 7 (7), 1545-1554.
- Lim, A., Guy, P.,
Makhov, A., Saderholm, M., Kroll, M., Yan, Y., Anderegg,
R., and Erickson, B.,
Engineering of Betabellin 15D: Copper(II)-induced Folding
of a Fibraller Beta-sandwich Protein. Lett.
Pep. Sci., 1999. 6 (1), 3-14.
- Nakhle, B., Vestal,
T., Saderholm, M., and Erickson, B., Synthesis of
an Iron(II)-braced Proline-II Tripod
Protein. Lett. Pep. Sci., 1999. 6 (1), 31-43.
- Saderholm, M. and
Erickson, B., Engineering of Deltoid and Reduced
Deltoid: Two Chimeric Proteins
Containing the Oligomerization Site of the Hepatitis
Delta Antigen. Lett. Pep. Sci., 1999. 6 (1) 23-30.
- Lim, A., Makhov, A.,
Saderholm, M., Griffith, J., and Erickson, B., Engineering
of Betabellin 16D: A Betasandwich
Protein that Forms Narrow Fibrils that Associate into
Broad Ribbons. Biochem. Biophys. Res.
Comm., 1999. 264, 498-504.
- Guy, P., Lim, A.,
Saderholm, M., Yan, Y., Erickson, B., and Anderegg,
R.J., Metal-Ion Binding and
Limited Proteolysis of Betabellin 15D, a Designed Beta-sandwich
Protein. J. Am. Soc. Mass Spec.,
1999. 10 (10), 969-974.
- Saderholm, M., Saconn,
P., Shah, N., and Erickson, B. Engineering of Cysteine-containing
Variants of
Quadrin and Deltoid, Two Proteins Containing the Oligomerization
Site of the Hepatitis Delta Antigen.
Peptides for the New Millennium (Proceedings of the
16th American Peptide Symposium), 2000. 463-
464.
- Saderholm, M., Hightower,
K., and Fierke, C., Protein Farnesyltransferase Exhibits
pH-dependent Activity Towards H-Ras Peptide Substrates. Biochemistry,
2000. 39(40), 12398-12405.
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| Research Programs |
- Design of new
computer-assisted experiments for undergraduate chemistry labs
- Molecular modeling
of peptides and proteins
- Engineering of
a new class of proline-containing cationic antimicrobial peptides
- Characterization
of the active compounds in regional ginseng samples
- Protein synthesis
using recombinant DNA techniques
- Enzymology of
farnesyltransferase
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